CHE2MCA T2 Chemistry Assignment Help
Question 1 (20 5 marks)
A. Explain thoroughly each step using the guide below for the known metabolic
pathways (i-v) of Meperidine. Give the type of metabolism and write the structures of
i) Hydrolysis of ester to acid (4 Marks)
ii) N-de-alkylation (4 Marks)
iii) Hydroxylation of aromatic ring (4 Marks)
v) N-oxidation (4 Marks)
iv) Conjugation of the phenolic products in iii with sulphate (4 Marks)
B. Which of the groups in propranolol can only act as a hydrogen bond acceptor? Give
the possible interaction of the different groups in the drug.
Question 2 (11 6 = 17 marks)
A. From a study carried out by Smith Kline
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